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Breakthrough Invasive Candidiasis in Children
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Severe infections due to Candida species have become more frequent during the past two decades because of the increasing numbers of immunosuppressed patients being treated in our hospitals. Distinguishing colonization from invasive disease requires knowledge of the pathogenetic mechanisms leading to invasion. To assist the clinician in therapeutic decisions, clinical microbiologists should iden...
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The epidemiology of Candida fungal infections is growing, due to the increasing size of the people at risk. Candida species are the fourth main cause of bloodstream infections; however, significant geographic differences have been reported. Although, in some instances, these changes may be related to medical interventions, such as the use of antifungal agents in prophylaxis, in the majority of ...
متن کاملLaboratory diagnosis of invasive candidiasis.
Invasive candidiasis is associated with high morbidity and mortality. Clinical diagnosis is complicated by a lack of specific clinical signs and symptoms of disease. Laboratory diagnosis is also complex because circulating antibodies to Candida species may occur in normal individuals as the result of commensal colonization of mucosal surfaces thereby reducing the usefulness of antibody detectio...
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ژورنال
عنوان ژورنال: Nature Reviews Disease Primers
سال: 2018
ISSN: 2056-676X
DOI: 10.1038/nrdp.2018.26